Images in Clinical Practice Indian Pediatrics 2006; 43:821 |
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Multiple Familial Tricho-epitheliomas |
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Trichoepitheliomas (syn: Brooke’s tumor) are benign adnexal tumors, possibly of folliculosebaceous-apocrine origin. They are slow growing and may be solitary or multiple. MFT is a rare autosomal dominant genodermatosis, linked to chromosome 9p21. The tumors appear in childhood and gradually increase in number. The diagnosis is based on the family history, clinical and histological findings. The clinical differentials include colloid milium, milia, pilar cyst, syringomas, steatocystoma multiplex and angiofibromas of tuberous sclerosis. Solitary lesions can be excised. Multiple lesions usually lead to marked disfigurement and the treatment options include electrosurgery, cryotherapy. dermabrasion, ablative lasers (such as erbium: Yag and CO2 laser) and split-thickness skin grafting. Such procedures result in flattening of lesions and good cosmetic outcome but recurrence may occur. Recently, topical therapy with a combination of imiquimod and tretinoin, has been reported to be effective. Amit Kumar Malhotra,
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