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Indian Pediatr 2015;52: 718-719 |
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Partial Splenic Artery Embolization for the
Management of Hypersplenism in Cirrhosis
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Padmasani Venkat Ramanan and *Vidya Krishna
Department of Pediatrics, Sri Ramachandra Medical
College, Porur, Chennai, TN, India.
Email:
[email protected]
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A 10-year-old boy presented with extrapyramidal movements of 6 months
duration. Wilson disease was confirmed by elevated 24 hours urinary
copper excretion after D-penicillamine
challenge. Ultrasonography of the abdomen revealed features of cirrhosis
with portal hypertension. He had pancytopenia (Hemoglobin 9.1 g /dL,
total leukocyte count 2×109/L
and platelet count 45×109/L.
Prothrombin time was elevated (20s, INR 1.6), but the liver enzymes were
normal. Patient was started on trihexyphenidyl,
D-penicillamine and
zinc. For management of pancytopenia due to the hypersplenism, partial
splenic artery embolization was done. The procedure was done under
conscious sedation using coils through right femoral
access. Post-procedure angiogram revealed partial occlusion of splenic
artery, slowing of splenic circulation and patent gastro-epiploic
artery. After 48 hrs, the patient developed post-embolization syndrome,
characterized by fever and pancreatitis (abdominal pain along with serum
amylase 214 U/L and lipase 895 U/L) which was managed symptomatically
with analgesics, antibiotics and intravenous fluids. The symptoms
subsided over next three weeks. Ten days after the procedure, the total
leukocyte count was 5.2x109/L
and platelet count was 135x109/L.
Treatment of hypersplenism requires medical
management of the primary disease. Splenectomy is associated with
significant post-operative morbidity, increased risk of portal vein
thrombosis, infections by encapsulated organisms and worsening hepatic
encephalopathy when hypersplenism is due to cirrhosis. Partial splenic
artery embolization (embolization of about 40-80% of the splenic tissue)
is a better option as the risk of infections and worsening of liver
function is reduced as some functioning splenic tissue is preserved. The
rise in blood counts usually occurs within two weeks after the
procedure. Post-embolization syndrome is the commonest complication
encountered in more than 75% of the patients [1,2]. It begins after 24
to 48 hours and lasts for several days. It is self-limited and is
managed conservatively. Other complications include pancreatitis, left
sided pleural effusion, portal vein thrombosis and splenic abscess [3].
Mortality rate is around 0-6% [1].
Acknowledgements: Dr Santhosh Joseph, Professor
and Head of Interventional Radiology and team for performing the
procedure; Dr Shuba, Professor and Head of Pediatric Intensive Care Unit
and team for post-operative management; and Dr Thambarasi, Junior
resident for overall patient management.
References
1. Hadduck TA, McWilliams JP. Partial splenic artery
embolization in cirrhotic patients. World J Radiol. 2014;6:160-8.
2. Smith M, Ray CE. Splenic artery embolization as an
adjunctive procedure for portal hypertension. Semin Intervent Radiol.
2012;29:135-9.
3. Khurana A, Abddel Khalek M, Brown J, Barry B,
Jaffe BM, Kandil E. Acute necrotizing pancreatitis following splenic
artery embolization. Trop Gastroenterol. 2011;32:226-9.
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